I'm blessed to have choices on what I shoot and the choice I'm making most of the time is to shoot my Ruger New Vaquero in 45 Colt. Not only does it just feel right packing around in the woods but it is plenty capable of anything I need a handgun to do.
By casting my own bullets and reloading I can feed it for less than $0.10/ round at the prices I paid for the components. Once they run out I'm not sure what it will cost at today's prices and availability...
I've shot 147 grain Round Balls, 200, 255, 280 and 300 grain bullets out of it. It won't handle "Ruger Only" loads like the Blackhawk so it isn't as versatile but a 255 grain bullet traveling between 850-1,000 fps will accomplish 99% of what I'd need a handgun cartridge to do.
The "Load" I've settled on is a 255 grain Lee RNFP pushed by SR4756 to 925fps average. It has proven to be accurate and easy to shoot.
At 25 yards it shoots point of aim. The group measures 1-3/4" and was shot offhand (two hands). Below the target is a three shot 147 grain Round Ball over Red Dot load. It travels 730 fps and prints about 8" below point of aim.
At 25 feet the 255 gr load shoots POA too. The RB load again prints lower.
5 shots 255 grain load centered. Two shots below are the Round Ball load.
Recently I've started shooting it at 100 yards. The delay between the muzzle blast and the thud/dirtsplash is adds to the grin factor My point of aim is about 3" above the paper. I line up the sights and then push the front sight post over the target. the target is mostly obscured so precision is reduced but I was able to shoot a 9 shot 8" group (loose sense of the word) Offhand (two handed) at 100 yards. One of the shots missed the paper, I suspect I touched it off my alignment was too low and it sailed below the target.
100 yard target
Ruger has captured the svelte good looks of the Colt and improved the durability making a near perfect "lead dispenser" in 45 Colt. Now I need one for my other hand.