Try to find honest to goodness wadcutters for .45 Colt and you'll likely have little success. I suggested to Bob Eichelman of MidAtlantic Bullets that he begin to carry them and he did! 200 grain, very nice bullets. Naturally there were no load suggestions on line, so I did some experimenting and found that 5.8 to 6.6 grains of VihtaVuori, N320 made for a very good load. It's expensive powder and no doubt, Titegroup, HP-38 or Universal can be substituted in proper amounts. But right now, I don't know what they would be.
The holes drilled in "orangepeel" targets at 60' are impressive to say the least. Nearly twice the size of RNFP bullets. And heavy duty Ruger cylinders are NOT necessary. I've fired hundreds of these in my 1858 Uberti.