First, I want to thank all who've responded here so far - your input is appreciated.
Second, it looks to me as though there might have been a little miscommunication. The .22 I'm looking for is *NOT* intended as a home-defense firearm, though if nothing else is available, of course it would be used as such. The best gun for defense is the one you have, and all that. However, the .22's primary purpose in life would be for plinking and practice. If worse comes to worst and Alison or Lori needs a firearm to defend against a home invader, the larger-caliber revolver we'll be getting for Lori would probably be better for that, and we'll be taking pains to ensure it's something Lori's comfortable with and both are willing to practice with. I'll be discussing the possibility of a long gun of some kind with her for in-home defensive use - I'd like to build an AR, I think, and would enjoy having a 7.62 rifle as well - but at this time, I doubt she'd be receptive to the idea. Due to hand size, Alison and Lori will almost certainly be sharing "their" guns.
I'd like to get back into rifle shooting as well as handgun (he says, not having been to the range in the month since picking up Dad's 1911

), and am idly contemplating trying 3-gun, which would mean getting a shotgun as well as a rifle-caliber carbine. That's for WAY down the road, though.